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Article

Predictive accuracy of combined genetic and environmental risk scores.

Genetic epidemiology - 1 Feb 2018

Dudbridge Frank, Pashayan Nora, Yang Jian

Abstract excerpt

The substantial heritability of most complex diseases suggests that genetic data could provide useful risk prediction. To date the performance of genetic risk scores has fallen short of the potential implied by heritability, but this can be explained by insufficient sample sizes for estimating highly polygenic models. When risk predictors already exist based on environment or lifestyle, two key questions are to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29178508
DOI: 10.1002/gepi.22092
PMCID: PMC5847122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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