Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy.

doi:10.1097/j.pain.0000000000001116

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy.

Pain - 1 Mar 2018

Blesneac Iulia, Themistocleous Andreas C, Fratter Carl, Conrad Linus J, Ramirez Juan D, Cox James J, Tesfaye Solomon, Shillo Pallai R, Rice Andrew S C, Tucker Stephen J, Bennett David L H

Abstract excerpt

Diabetic peripheral neuropathy (DPN) is a common disabling complication of diabetes. Almost half of the patients with DPN develop neuropathic pain (NeuP) for which current analgesic treatments are inadequate. Understanding the role of genetic variability in the development of painful DPN is needed for improved understanding of pain pathogenesis for better patient stratification in clinical trials and to target...

Topics

Adult
Aged
Cohort Studies
Diabetic Neuropathies
Female
Genetic Association Studies
Genetic Variation
HEK293 Cells
Humans
Male
Membrane Potentials

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Models, Molecular

Mutagenesis, Site-Directed

NAV1.7 Voltage-Gated Sodium Channel

Pain Measurement

Patch-Clamp Techniques

Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 29176367
DOI: 10.1097/j.pain.0000000000001116
PMCID: PMC5828379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-29176367-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare NaV1.7 variants associated with painful diabetic peripheral neuropathy.PMID 29176367Read ↗

A gain-of-function sodium channel β 2-subunit mutation in painful diabetic neuropathySemantic proximity Read ↗

Sodium channelopathies and pain.Semantic proximity Read ↗

Peripheral Ion Channel Gene Screening in Painful- and Painless-Diabetic NeuropathySemantic proximity Read ↗

Gain-of-function Nav1.8 mutations in painful neuropathy.Semantic proximity Read ↗

Human pain channelopathies.Semantic proximity Read ↗

Gain-of-function mutations in sodium channel NaV1.9 in painful neuropathySemantic proximity Read ↗

Painful and painless channelopathies.Semantic proximity Read ↗

Intra- and interfamily phenotypic diversity in pain syndromes associated with a gain-of-function variant of NaV1.7.Semantic proximity Read ↗

Genetic, electrophysiological, and pathological studies on patients with SCN9A-related pain disorders.Semantic proximity Read ↗

SCN9A Variants May be Implicated in Neuropathic Pain Associated With Diabetic Peripheral Neuropathy and Pain Severity.Semantic proximity Read ↗

Investigating genotype–phenotype relationship of extreme neuropathic pain disorders in a UK national cohortSemantic proximity Read ↗

Carriers of<i>SCN9A</i>variants linked to inherited and acquired pain syndromes show no alteration in the prevalence of pain or analgesic usage in the UK Biobank cohortSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.