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Article

A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.

Atherosclerosis - 1 Aug 2016

Goettsch Claudia, Hutcheson Joshua D, Hagita Sumihiko, Rogers Maximillian A, Creager Michael D, Pham Tan, Choi Jung, Mlynarchik Andrew K, Pieper Brett, Kjolby Mads, Aikawa Masanori, Aikawa Elena

Abstract excerpt

BACKGROUND AND AIMS: Studying atherosclerotic calcification in vivo requires mouse models with genetic modifications. Previous studies showed that injection of recombinant adeno-associated virus vector (AAV) encoding a gain-of-function mutant PCSK9 into mice promotes atherosclerosis. We aimed to study cardiovascular calcification induced by PCSK9 AAV in C57BL/6J mice. METHODS: 10 week-old C57BL/6J mice received a...

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Identifiers

PMID: 27318830
DOI: 10.1016/j.atherosclerosis.2016.06.011
PMCID: PMC4983246

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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