Article
Stochastic phenotype switching leads to intratumor heterogeneity in human liver cancer.
Hepatology (Baltimore, Md.) - 1 Sept 2018
Matak Andrija, Lahiri Pooja, Ford Ethan, Pabst Daniela, Kashofer Karl, Stellas Dimitris, Thanos Dimitris, Zatloukal Kurt
Abstract excerpt
Intratumor heterogeneity is increasingly recognized as a major factor impacting diagnosis and personalized treatment of cancer. We characterized stochastic phenotype switching as a mechanism contributing to intratumor heterogeneity and malignant potential of liver cancer. Clonal analysis of primary tumor cell cultures of a human sarcomatoid cholangiocarcinoma identified different types of self-propagating...
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