Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

doi:10.1038/s41467-017-02002-4

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Article

Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling.

Nature communications - 24 Nov 2017

Berenjeno Inma M, Piñeiro Roberto, Castillo Sandra D, Pearce Wayne, McGranahan Nicholas, Dewhurst Sally M, Meniel Valerie, Birkbak Nicolai J, Lau Evelyn, Sansregret Laurent, Morelli Daniele, Kanu Nnennaya, Srinivas Shankar, Graupera Mariona, Parker Victoria E R, Montgomery Karen G, Moniz Larissa S, Scudamore Cheryl L, Phillips Wayne A, Semple Robert K, Clarke Alan, Swanton Charles, Vanhaesebroeck Bart

Abstract excerpt

Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of mutant PIK3CA during early stages of malignancy is unknown. Using a mouse model to activate the Pik3ca H1047R hotspot mutation in the heterozygous state from its endogenous locus, we here report that mutant Pik3ca induces centrosome amplification in cultured cells (through a pathway...

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PMID: 29170395
DOI: 10.1038/s41467-017-02002-4
PMCID: PMC5701070

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CDK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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