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Article

A changing signaling environment induces multiciliated cell trans-differentiation during developmental remodeling

2020-04-18

Abstract excerpt

Multiciliated cells (MCCs) are extremely highly-differentiated, presenting >100 cilia and basal bodies. We analyzed how MCCs are lost from the airway-like Xenopus embryonic epidermis during developmental tissue remodeling. We found that some MCCs undergo apoptosis, but that the majority trans-differentiate into secretory cells. Trans-differentiation involves loss of ciliary gene expression, cilia retraction and l...

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Literature Corpus work
d355fb9f-917b-57b1-9227-12e31d94dc87
DOI
10.1101/2020.04.16.045401
Open publication

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A changing signaling environment induces multiciliated cell trans-differentiation during developmental remodelingDOI 10.1101/2020.04.16.045401
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