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Article

Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.

Stem cell reports - 12 Dec 2017

Muratore Christina R, Zhou Constance, Liao Meichen, Fernandez Marty A, Taylor Walter M, Lagomarsino Valentina N, Pearse Richard V, Rice Heather C, Negri Joseph M, He Amy, Srikanth Priya, Callahan Dana G, Shin Taehwan, Zhou Monica, Bennett David A, Noggle Scott, Love J Christopher, Selkoe Dennis J, Young-Pearse Tracy L

Abstract excerpt

Alzheimer's disease (AD) induces memory and cognitive impairment in the absence of motor and sensory deficits during its early and middle course. A major unresolved question is the basis for this selective neuronal vulnerability. Aβ, which plays a central role in AD pathogenesis, is generated throughout the brain, yet some regions outside of the limbic and cerebral cortices are relatively spared from Aβ plaque...

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Identifiers

PMID: 29153990
DOI: 10.1016/j.stemcr.2017.10.015
PMCID: PMC5785690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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