Article
Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia.
Cell research - 1 Feb 2018
Huang Liang, Liu Dan, Wang Na, Ling Shaoping, Tang Yuting, Wu Jun, Hao Lingtong, Luo Hui, Hu Xuelian, Sheng Lingshuang, Zhu Lijun, Wang Di, Luo Yi, Shang Zhen, Xiao Min, Mao Xia, Zhou Kuangguo, Cao Lihua, Dong Lili, Zheng Xinchang, Sui Pinpin, He Jianlin, Mo Shanlan, Yan Jin, Ao Qilin, Qiu Lugui, Zhou Hongsheng, Liu Qifa, Zhang Hongyu, Li Jianyong, Jin Jie, Fu Li, Zhao Weili, Chen Jieping, Du Xin, Qing Guoliang, Liu Hudan, Liu Xin, Huang Gang, Ma Ding, Zhou Jianfeng, Wang Qian-Fei
Abstract excerpt
Aggressive NK-cell leukemia (ANKL) is a rare form of NK cell neoplasm that is more prevalent among people from Asia and Central and South America. Patients usually die within days to months, even after receiving prompt therapeutic management. Here we performed the first comprehensive study of ANKL by integrating whole genome, transcriptome and targeted sequencing, cytokine array as well as functional assays....
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