Genetic and Clinical Distinction between Aggressive NK-cell Leukemia and Extranodal NK/T-cell Lymphoma with Bone Marrow Involvement

Abstract excerpt

<title>Abstract</title> <p>Aggressive NK-cell leukemia (ANKL) shares common clinicopathological features with extranodal NK/T-cell lymphoma with bone marrow (BM) involvement (ENKTL-BM), making their distinction challenging in BM examination. Despite numerous studies, genetic differences between the two diseases remained largely unclear. To investigate the genetic and clinical differences between ANKL and ENKTL-BM...

Topics

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• Biomarkers, Tumor
• Cytogenetic Analysis
• Disease Progression
• High-Throughput Nucleotide Sequencing
• Immune Cell Function and Interaction
• Immunohistochemistry
• Lymphoma Diagnosis and Treatment
• T-cell and Retrovirus Studies

Identifiers and source

Literature Corpus work

fc8078ae-4d82-5902-8fb2-b6848ec85fe2

DOI

10.21203/rs.3.rs-5740535/v1