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Article

Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation.

Clinical and experimental pharmacology & physiology - 1 May 2018

Shang Dongsheng, Wu Yanfang, Ding Ya, Lu Ziwen, Shen Yanting, Zhu Feifei, Liu Hanqing, Zhu Chunyin, Tu Zhigang

Abstract excerpt

Cellular senescence is a state of irreversible cell growth arrest. Increasing evidence suggests that cellular senescence contribute to tumour suppression in vivo. However, only a few anti-cancer drugs have been discovered to induce cellular senescence. Searching for new compounds which can inhibit cancer cell growth by inducing senescence is becoming one of the most attractive research fields. To test the effects...

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Identifiers

PMID: 29143360
DOI: 10.1111/1440-1681.12891

Genes

MMP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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