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Article

Novel targeted therapeutics for MEN2

18 Jan 2018

Abstract excerpt

) proto-oncogene was recognized as the multiple endocrine neoplasia type 2 (MEN2) causing gene in 1993. Since then, much effort has been put into a clear understanding of its oncogenic signaling, its biochemical function and ways to block its aberrant activation in MEN2 and related cancers. Several small molecules have been designed, developed or redirected as RET inhibitors for the treatment of MEN2 and sporadic...

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PMID: 29348306
DOI: 10.1530/erc-17-0297

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