Article
Advances in the management of hereditary medullary thyroid cancer.
Journal of internal medicine - 1 Jan 2005
Machens A, Ukkat J, Brauckhoff M, Gimm O, Dralle H
Abstract excerpt
This work draws on recent advances during the era of codon-oriented prophylactic surgery for hereditary medullary thyroid cancer (MTC). Milestones included identification of RET (REarranged during Transfection) as the susceptibility gene, introduction of prophylactic surgery on evidence of a RET germline mutation, revelation of genotype-phenotype correlations within the MEN 2 spectrum and demonstration of...
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