Article
RBM45 competes with HDAC1 for binding to FUS in response to DNA damage.
Nucleic acids research - 15 Dec 2017
Gong Juanjuan, Huang Min, Wang Fengli, Ma Xiaolu, Liu Hongmei, Tu Yingfeng, Xing Lingyu, Zhu Xuefei, Zheng Hui, Fang Junjie, Li Xiaoling, Wang Qiaochu, Wang Jiuqiang, Sun Zhongshuai, Wang Xi, Wang Yun, Guo Caixia, Tang Tie-Shan
Abstract excerpt
DNA damage response (DDR) is essential for genome stability and human health. Recently, several RNA binding proteins (RBPs), including fused-in-sarcoma (FUS), have been found unexpectedly to modulate this process. The role of FUS in DDR is closely linked to the pathogenesis of amyotrophic lateral sclerosis (ALS), a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord....
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