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Article

RBM45 homo-oligomerization mediates association with ALS-linked proteins and stress granules.

Scientific reports - 22 Sept 2015

Li Yang, Collins Mahlon, Geiser Rachel, Bakkar Nadine, Riascos David, Bowser Robert

Abstract excerpt

The aggregation of RNA-binding proteins is a pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). RBM45 is an RNA-binding protein that forms cytoplasmic inclusions in neurons and glia in ALS and FTLD. To explore the role of RBM45 in ALS and FTLD, we examined the contribution of the protein's domains to its function, subcellular localization, and interaction...

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Topics

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Share to Active Transport, Cell Nucleus
Share to Inclusion Bodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Localization Signals

Share to Protein Aggregation, Pathological

Share to Protein Interaction Domains and Motifs

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Share to Protein Multimerization

Share to RNA-Binding Protein FUS

Source

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Identifiers

PMID: 26391765
DOI: 10.1038/srep14262
PMCID: PMC4585734

Genes

RBM45
FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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