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Article

SUMOylation regulates the localization and activity of Polo-like kinase 1 during cell cycle in the silkworm, Bombyx mori.

Scientific reports - 14 Nov 2017

Li Zhiqing, Cui Qixin, Xu Jian, Cheng Daojun, Wang Xiaoyan, Li Bingqian, Lee Jae Man, Xia Qingyou, Kusakabe Takahiro, Zhao Ping

Abstract excerpt

Polo-like kinase 1 (Plk1) is a crucial cell cycle regulator by its specific localization and activity during cell cycle. It has been shown that the phosphorylation and ubiquitylation of Plk1 are required for its own activation and localization. Here, we report that SUMOylation regulates the activity of Plk1 in the lepidopteran insect of Bombyx mori. In the absence of SUMOylation, it causes the lost localization...

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Identifiers

PMID: 29138491
DOI: 10.1038/s41598-017-15884-7
PMCID: PMC5686133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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