Article
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.
Nature cell biology - 1 Feb 2007
Fulga Tudor A, Elson-Schwab Ilan, Khurana Vikram, Steinhilb Michelle L, Spires Tara L, Hyman Bradley T, Feany Mel B
Abstract excerpt
Hyperphosphorylated forms of the microtubule-associated protein (MAP) tau accumulate in Alzheimer's disease and related tauopathies and are thought to have an important role in neurodegeneration. However, the mechanisms through which phosphorylated tau induces neurodegeneration have remained elusive. Here, we show that tau-induced neurodegeneration is associated with accumulation of filamentous actin (F-actin)...
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