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Article

High parathyroid hormone concentration in tenofovir-treated patients are due to inhibition of calcium-sensing receptor activity.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jan 2018

Mingione Alessandra, Maruca Katia, Chiappori Federica, Pivari Francesca, Brasacchio Caterina, Quirino Tiziana, Merelli Ivan, Soldati Laura, Bonfanti Paolo, Mora Stefano

Abstract excerpt

Bone health impairment is a common finding in HIV-infected patients on antiretroviral treatment. High serum parathyroid hormone (PTH) concentration in patients on antiretroviral treatment containing tenofovir disoproxil fumarate (TDF) has been reported. Hyperparathyroidism was not always sustained by a reduction in vitamin D concentration. We thus hypothesized a direct inhibitory effect of TDF on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29136775
DOI: 10.1016/j.biopha.2017.11.037

Genes

CASR
PTH

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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