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Article

Alanine scanning mutational analysis of the ligand binding pocket of the human Vitamin D receptor.

The Journal of steroid biochemistry and molecular biology - 1 Mar 2007

Yamamoto Keiko, Choi Mihwa, Abe Daijiro, Shimizu Masato, Yamada Sachiko

Abstract excerpt

We achieved exhaustive alanine scanning mutational analysis of the amino acid residues lining the ligand binding pocket of the Vitamin D receptor to investigate the mechanism of the ligand recognition by the receptor. This is the first exhaustive analysis in the nuclear receptor superfamily. Our results demonstrated the role and importance of all the residues lining the ligand binding pocket. In addition, this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17223344
DOI: 10.1016/j.jsbmb.2006.12.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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