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Article

Transcriptional activation of the wild-type and mutant vitamin D receptors by vitamin D3 analogs.

Journal of molecular endocrinology - 1 Jul 2016

Futawaka Kumi, Tagami Tetsuya, Fukuda Yuki, Koyama Rie, Nushida Ayaka, Nezu Shoko, Yamamoto Hironori, Imamoto Miyuki, Kasahara Masato, Moriyama Kenji

Abstract excerpt

The active form of vitamin D3 (1α,25(OH)2D3, also known as calcitriol) controls the expression of target genes via the vitamin D receptor (VDR). Vitamin D-dependent rickets type II (VDDRII) is a congenital disease caused by inactivating mutations in the VDR The condition is treated with high doses of calcitriol, but the therapeutic effects of other synthetic VD3 analogs have not yet been investigated. In the...

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Share to 25-Hydroxyvitamin D3 1-alpha-Hydroxylase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Promoter Regions, Genetic

Share to Receptors, Calcitriol

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Source

Identifiers

PMID: 27154546
DOI: 10.1530/JME-16-0048

Genes

VDR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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