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Article

Pancreatic cancer and a novel MSH2 germline alteration.

Pancreas - 1 Oct 2011

Lindor Noralane M, Petersen Gloria M, Spurdle Amanda B, Thompson Bryony, Goldgar David E, Thibodeau Stephen N

Abstract excerpt

OBJECTIVE: The objective of this study was to describe a novel MSH2 missense alteration cosegregating with pancreatic cancer. METHODS: The method used was an observational study of a kindred in which a novel MSH2 missense alteration was identified. RESULTS: We report a family in which a MSH2 P349L missense alteration is cosegregating with pancreatic cancers among 3 nonsmoking first-degree relatives. Lynch...

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Topics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Heredity

Share to Immunohistochemistry

Share to Mutation, Missense

Share to MutS Homolog 2 Protein

Share to Pancreatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 21926548
DOI: 10.1097/MPA.0b013e318220c217
PMCID: PMC3425611

Genes

MSH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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