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Article

DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression.

Psychoneuroendocrinology - 1 Feb 2018

Lam Dilys, Ancelin Marie-Laure, Ritchie Karen, Saffery Richard, Ryan Joanne

Abstract excerpt

BACKGROUND: Depression is one of the most prevalent psychiatric disorders, and in older persons is associated with high levels of comorbidity and under-treatment. Dysfunction of the hypothalamic-pituitary-adrenal (HPA) stress axis is consistently observed in the older population as well as depressed patients, with the angiotensin converting enzyme (ACE) a key regulator of the stress response. Epigenetic...

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Identifiers

PMID: 29132028
DOI: 10.1016/j.psyneuen.2017.11.003

Genes

ACE

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