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Article

Unraveling the epigenetic landscape of depression: focus on early life stress .

Dialogues in clinical neuroscience - 1 Dec 2019

Torres-Berrío Angélica, Issler Orna, Parise Eric M, Nestler Eric J

Abstract excerpt

Depression is a devastating psychiatric disorder caused by a combination of genetic predisposition and life events, mainly exposure to stress. Early life stress (ELS) in particular is known to "scar" the brain, leading to an increased susceptibility to developing depression later in life via epigenetic mechanisms. Epigenetic processes lead to changes in gene expression that are not due to changes in DNA sequence,...

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Identifiers

PMID: 31949402
DOI: 10.31887/DCNS.2019.21.4/enestler
PMCID: PMC6952747

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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