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Article

The mitochondrial metabolic reprogramming agent trimetazidine as an 'exercise mimetic' in cachectic C26-bearing mice.

Journal of cachexia, sarcopenia and muscle - 1 Dec 2017

Molinari Francesca, Pin Fabrizio, Gorini Stefania, Chiandotto Sergio, Pontecorvo Laura, Penna Fabio, Rizzuto Emanuele, Pisu Simona, Musarò Antonio, Costelli Paola, Rosano Giuseppe, Ferraro Elisabetta

Abstract excerpt

BACKGROUND: Cancer cachexia is characterized by muscle depletion and exercise intolerance caused by an imbalance between protein synthesis and degradation and by impaired myogenesis. Myofibre metabolic efficiency is crucial so as to assure optimal muscle function. Some drugs are able to reprogram cell metabolism and, in some cases, to enhance metabolic efficiency. Based on these premises, we chose to investigate...

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Identifiers

PMID: 29130633
DOI: 10.1002/jcsm.12226
PMCID: PMC5700442

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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