Article
Efficacy of hepatitis B virus ribonuclease H inhibitors, a new class of replication antagonists, in FRG human liver chimeric mice.
Antiviral research - 1 Jan 2018
Long Kelly R, Lomonosova Elena, Li Qilan, Ponzar Nathan L, Villa Juan A, Touchette Erin, Rapp Stephen, Liley R Matt, Murelli Ryan P, Grigoryan Alexandre, Buller R Mark, Wilson Lisa, Bial John, Sagartz John E, Tavis John E
Abstract excerpt
Chronic hepatitis B virus infection cannot be cured by current therapies, so new treatments are urgently needed. We recently identified novel inhibitors of the hepatitis B virus ribonuclease H that suppress viral replication in cell culture. Here, we employed immunodeficient FRG KO mice whose livers had been engrafted with primary human hepatocytes to ask whether ribonuclease H inhibitors can suppress hepatitis B...
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