Article
Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience.
Clinical colorectal cancer - 1 Mar 2018
Chiu Joanne W, Krzyzanowska Monika K, Serra Stefano, Knox Jennifer J, Dhani Neesha C, Mackay Helen, Hedley David, Moore Malcolm, Liu Geoffrey, Burkes Ronald L, Brezden-Masley Christine, Roehrl Michael H, Craddock Kenneth J, Tsao Ming-Sound, Zhang Tong, Yu Celeste, Kamel-Reid Suzanne, Siu Lillian L, Bedard Philippe L, Chen Eric X
Abstract excerpt
BACKGROUND: Molecular aberrations in KRAS, NRAS, BRAF, and PIK3CA have been well-described in advanced colorectal cancer. The incidences of other mutations are less known. We report results of molecular profiling of advanced colorectal cancer in an academic cancer center. PATIENTS AND METHODS: Pa...
Topics
- Adult
- Aged
- Biomarkers, Tumor
- Colorectal Neoplasms
- DNA Mutational Analysis
- Female
- Gene Expression Profiling
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Mutation
- Transcriptome