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Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway

25 May 2017

Abstract excerpt

High risk human papilloma viruses cause several types of cancer. The HPV oncoproteins E6 and E7 are essential for oncogenic cell transformation. E6 mediates the degradation of the tumor suppressor p53, and E7 can form complexes with the retinoblastoma pRB tumor suppressor. Recently, it has been shown that HPV E7 can also interfere with the function of the DREAM transcriptional repressor complex. Disruption of...

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PMID: 28572607
DOI: 10.1038/s41598-017-02831-9

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