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A Mechanism for Priming and Realignment during Influenza A Virus Replication

8 Nov 2017

Abstract excerpt

ABSTRACT The influenza A virus genome consists of eight segments of single-stranded RNA. These segments are replicated and transcribed by a viral RNA-dependent RNA polymerase (RdRp) that is made up of the influenza virus proteins PB1, PB2, and PA. To copy the viral RNA (vRNA) genome segments and the cRNA segments, the replicative intermediate of viral replication, the RdRp must use two promoters and two different...

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PMID: 29118119
DOI: 10.1128/jvi.01773-17

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