Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Depletion of somatic mutations in splicing-associated sequences in cancer genomes.

Genome biology - 7 Nov 2017

Hurst Laurence D, Batada Nizar N

Abstract excerpt

BACKGROUND: An important goal of cancer genomics is to identify systematically cancer-causing mutations. A common approach is to identify sites with high ratios of non-synonymous to synonymous mutations; however, if synonymous mutations are under purifying selection, this methodology leads to identification of false-positive mutations. Here, using synonymous somatic mutations (SSMs) identified in over 4000...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Enhancer Elements, Genetic
Share to Exome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Neoplasms

Share to Nucleotide Motifs

Share to RNA Splicing

Source

Open in PubMed Open full text

Identifiers

PMID: 29115978
DOI: 10.1186/s13059-017-1337-5
PMCID: PMC5678748

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Depletion of somatic mutations in splicing-associated sequences in cancer genomes.PMID 29115978Read ↗

Synonymous Variants: Necessary Nuance in Our Understanding of Cancer Drivers and Treatment Outcomes.Semantic proximity Read ↗

Reduced mutation rate in exons due to differential mismatch repair.Semantic proximity Read ↗

A comprehensive characterization of cis-acting splicing-associated variants in human cancerSemantic proximity Read ↗

Detecting and understanding meaningful cancerous mutations based on computational models of mRNA splicingSemantic proximity Read ↗

Synonymous Somatic Variants in Human Cancer Are Not Infamous: A Plea for Full Disclosure in Databases and Publications.Semantic proximity Read ↗

Effect Sizes of Somatic Mutations in CancerSemantic proximity Read ↗

Allelic imbalance of somatic mutations in cancer genomes and transcriptomes.Semantic proximity Read ↗

The landscape of somatic mutations in protein coding genes in apparently benign human tissues carries signatures of relaxed purifying selectionSemantic proximity Read ↗

Systematic pan-cancer analysis of somatic allele frequency.Semantic proximity Read ↗

Mutation patterns in cancer genomes.Semantic proximity Read ↗

DNA replication timing and selection shape the landscape of nucleotide variation in cancer genomes.Semantic proximity Read ↗

Detecting and understanding meaningful cancerous mutations based on computational models of mRNA splicing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.