A comprehensive analysis of polymorphic variants in steroid hormone and insulin-like growth factor-1 metabolism and risk of in situ breast cancer: Results from the Breast and Prostate Cancer Cohort Consortium.

doi:10.1002/ijc.31145

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A comprehensive analysis of polymorphic variants in steroid hormone and insulin-like growth factor-1 metabolism and risk of in situ breast cancer: Results from the Breast and Prostate Cancer Cohort Consortium.

International journal of cancer - 15 Mar 2018

Barrdahl Myrto, Canzian Federico, Gaudet Mia M, Gapstur Susan M, Trichopoulou Antonia, Tsilidis Kostas, van Gils Carla H, Borgquist Signe, Weiderpass Elisabete, Khaw Kay-Tee, Giles Graham G, Milne Roger L, Le Marchand Loic, Haiman Christopher, Lindström Sara, Kraft Peter, Hunter David J, Ziegler Regina, Chanock Stephen J, Yang Xiaohong R, Buring Julie E, Lee I-Min, Kaaks Rudolf, Campa Daniele

Abstract excerpt

We assessed the association between 1,414 single nucleotide polymorphisms (SNPs) in genes involved in synthesis and metabolism of steroid hormones and insulin-like growth factor 1, and risk of breast cancer in situ (BCIS), with the aim of determining whether any of these were disease specific. This was carried out using 1,062 BCIS cases and 10,126 controls as well as 6,113 invasive breast cancer cases from the...

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PMID: 29114882
DOI: 10.1002/ijc.31145
PMCID: PMC6610718

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INSR
PML
MAST2

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