Article
The RNA processing factors THRAP3 and BCLAF1 promote the DNA damage response through selective mRNA splicing and nuclear export.
Nucleic acids research - 15 Dec 2017
Vohhodina Jekaterina, Barros Eliana M, Savage Abigail L, Liberante Fabio G, Manti Lorenzo, Bankhead Peter, Cosgrove Nicola, Madden Angelina F, Harkin D Paul, Savage Kienan I
Abstract excerpt
mRNA splicing and export plays a key role in the regulation of gene expression, with recent evidence suggesting an additional layer of regulation of gene expression and cellular function through the selective splicing and export of genes within specific pathways. Here we describe a role for the RNA processing factors THRAP3 and BCLAF1 in the regulation of the cellular DNA damage response (DDR) pathway, a key...
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