TLR9 -1486T/C and 2848C/T SNPs Are Associated with Human Cytomegalovirus Infection in Infants.

doi:10.1371/journal.pone.0154100

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Article

TLR9 -1486T/C and 2848C/T SNPs Are Associated with Human Cytomegalovirus Infection in Infants.

PloS one - 1 Jan 2016

Paradowska Edyta, Jabłońska Agnieszka, Studzińska Mirosława, Skowrońska Katarzyna, Suski Patrycja, Wiśniewska-Ligier Małgorzata, Woźniakowska-Gęsicka Teresa, Nowakowska Dorota, Gaj Zuzanna, Wilczyński Jan, Leśnikowski Zbigniew J

Abstract excerpt

Toll-like receptor 9 (TLR9) recognizes non-methylated viral CpG-containing DNA and serves as a pattern recognition receptor that signals the presence of human cytomegalovirus (HCMV). Here, we present the genotype distribution of single-nucleotide polymorphisms (SNPs) of the TLR9 gene in infants and the relationship between TLR9 polymorphisms and HCMV infection. Four polymorphisms (-1237T/C, rs5743836; -1486T/C,...

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PMID: 27105145
DOI: 10.1371/journal.pone.0154100
PMCID: PMC4841553

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