Article
The population genetics of chronic kidney disease: insights from the MYH9-APOL1 locus.
Nature reviews. Nephrology - 1 Jun 2011
Rosset Saharon, Tzur Shay, Behar Doron M, Wasser Walter G, Skorecki Karl
Abstract excerpt
Many rare kidney disorders exhibit a monogenic, Mendelian pattern of inheritance. Population-based genetic studies have identified many genetic variants associated with an increased risk of developing common kidney diseases. Strongly associated variants have potential clinical uses as predictive markers and may advance our understanding of disease pathogenesis. These principles are elegantly illustrated by a...
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