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Notch3 Maintains Luminal Phenotype and Suppresses Tumorigenesis and Metastasis of Breast Cancer via Trans-Activating Estrogen Receptor-α

1 Jan 2017

Abstract excerpt

The luminal A phenotype is the most common breast cancer subtype and is characterized by estrogen receptor expression (ER). Identification of the key regulator that governs the luminal phenotype of breast cancer will clarify the pathogenic mechanism and provide novel therapeutic strategies for this subtype of cancer. ER signaling pathway sustains the epithelial phenotype and inhibits the epithelial-mesenchymal...

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Identifiers

PMID: 29109797
DOI: 10.7150/thno.19989

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Related research

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Research trail→

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Notch3 Maintains Luminal Phenotype and Suppresses Tumorigenesis and Metastasis of Breast Cancer via Trans-Activating Estrogen Receptor-αPMID 29109797Read ↗

Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancerSemantic proximity Read ↗

A “NOTCH” Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast CancerSemantic proximity Read ↗

Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch.Semantic proximity Read ↗

A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behaviorSemantic proximity Read ↗

FOXA1 represses the molecular phenotype of basal breast cancer cells.Semantic proximity Read ↗

TRIM3 Facilitates Estrogen Signaling and Modulates Breast Cancer Cell ProgressionSemantic proximity Read ↗

Loss of Dickkopf 3 Promotes the Tumorigenesis of Basal Breast CancerSemantic proximity Read ↗

The ELK3-GATA3 axis orchestrates invasion and metastasis of breast cancer cells <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read ↗

Notch1 induces epithelial-mesenchymal transition and the cancer stem cell phenotype in breast cancer cells and STAT3 plays a key role.Semantic proximity Read ↗

The differentiation status of luminal-type breast cancer–derived organoids can be altered in vitro through the activation of NOTCH signalingSemantic proximity Read ↗

Emerin expression stratification across breast cancer subtypesSemantic proximity Read ↗

Targeting Met and Notch in the<i>Lfng</i>-deficient,<i>Met</i>-amplified triple-negative breast cancerSemantic proximity Read ↗

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