Article
FOXA1 represses the molecular phenotype of basal breast cancer cells.
Oncogene - 31 Jan 2013
Bernardo G M, Bebek G, Ginther C L, Sizemore S T, Lozada K L, Miedler J D, Anderson L A, Godwin A K, Abdul-Karim F W, Slamon D J, Keri R A
Abstract excerpt
Breast cancer is a heterogeneous disease that comprises multiple subtypes. Luminal subtype tumors confer a more favorable patient prognosis, which is, in part, attributed to estrogen receptor (ER)-α positivity and antihormone responsiveness. Expression of the forkhead box transcription factor, FOXA1, similarly correlates with the luminal subtype and patient survival, but is also present in a subset of ER-negative...
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