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Article

PKCδ/midkine pathway drives hypoxia-induced proliferation and differentiation of human lung epithelial cells.

American journal of physiology. Cell physiology - 1 Apr 2014

Zhang Hanying, Okamoto Miyako, Panzhinskiy Evgeniy, Zawada W Michael, Das Mita

Abstract excerpt

Epithelial cells are key players in the pathobiology of numerous hypoxia-induced lung diseases. The mechanisms mediating such hypoxic responses of epithelial cells are not well characterized. Earlier studies reported that hypoxia stimulates protein kinase C (PKC)δ activation in renal cancer cells and an increase in expression of a heparin-binding growth factor, midkine (MK), in lung alveolar epithelial cells. We...

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Identifiers

PMID: 24500281
DOI: 10.1152/ajpcell.00351.2013
PMCID: PMC3962599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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