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Article

Analysis of a comprehensive dataset of diversity generating retroelements generated by the program DiGReF.

BMC genomics - 28 Aug 2012

Schillinger Thomas, Lisfi Mohamed, Chi Jingyun, Cullum John, Zingler Nora

Abstract excerpt

BACKGROUND: Diversity Generating Retroelements (DGRs) are genetic cassettes that can introduce tremendous diversity into a short, defined region of the genome. They achieve hypermutation through replacement of the variable region with a strongly mutated cDNA copy generated by the element-encoded reverse transcriptase. In contrast to "selfish" retroelements such as group II introns and retrotransposons, DGRs...

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Identifiers

PMID: 22928525
DOI: 10.1186/1471-2164-13-430
PMCID: PMC3521204

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