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Metabolomic analysis in Amycolatopsis keratiniphila disrupted the competing ECO0501 pathway for enhancing the accumulation of vancomycin.

World journal of microbiology & biotechnology - 10 Aug 2024

Chen Shuo, Rao Min, Jin Wenxiang, Hu Mengyi, Chen Daijie, Ge Mei, Mao Wenwei, Qian Xiuping

Abstract excerpt

Vancomycin is a clinically important glycopeptide antibiotic against Gram-positive pathogenic bacteria, especially methicillin-resistant Staphylococcus aureus. In the mutant strain of Amycolatopsis keratiniphila HCCB10007 Δeco-cds4-27, the production of ECO-0501 was disrupted, but enhanced vancomycin yield by 55% was observed compared with the original strain of A. keratiniphila HCCB10007. To gain insights into...

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PMID: 39126539
DOI: 10.1007/s11274-024-04105-9

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