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Article

Chlorflavonin Targets Acetohydroxyacid Synthase Catalytic Subunit IlvB1 for Synergistic Killing of Mycobacterium tuberculosis.

ACS infectious diseases - 9 Feb 2018

Rehberg Nidja, Akone Herve Sergi, Ioerger Thomas R, Erlenkamp German, Daletos Georgios, Gohlke Holger, Proksch Peter, Kalscheuer Rainer

Abstract excerpt

The flavonoid natural compound chlorflavonin was isolated from the endophytic fungus Mucor irregularis, which was obtained from the Cameroonian medicinal plant Moringa stenopetala. Chlorflavonin exhibited strong growth inhibitory activity in vitro against Mycobacterium tuberculosis (MIC90 1.56 μM) while exhibiting no cytotoxicity toward the human cell lines MRC-5 and THP-1 up to concentrations of 100 μM. Mapping...

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PMID: 29108416
DOI: 10.1021/acsinfecdis.7b00055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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