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Naturally occurring Dinactin targets cpsA of LytR-Cps2A-Psr family protein as well as kills Mycobacterium tuberculosis by disrupting proton motive force

2023-02-22

Abstract excerpt

Tuberculosis is still a global threat, and new drugs are desperately needed to combat the spread of multidrug-resistant Mycobacterium tuberculosis. Historically, natural products have been an important source of drugs against infectious diseases, like tuberculosis. Here, we identified a natural macrotetrolide dinactin with antituberculosis activity against susceptible and non-replicating Mycobacterium tuberculosis...

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Literature Corpus work
274a9679-079c-5943-b626-57995ebc3b54
DOI
10.21203/rs.3.rs-2295387/v1
Open publication

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Naturally occurring Dinactin targets cpsA of LytR-Cps2A-Psr family protein as well as kills Mycobacterium tuberculosis by disrupting proton motive forceDOI 10.21203/rs.3.rs-2295387/v1
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