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Article

A bell-shaped dependence between amyloidosis and GABA accumulation in astrocytes in a mouse model of Alzheimer's disease.

Neurobiology of aging - 1 Jan 2018

Brawek Bianca, Chesters Robert, Klement Daniel, Müller Julia, Lerdkrai Chommanad, Hermes Marina, Garaschuk Olga

Abstract excerpt

Functioning at the interface between the nervous and immune systems, in the amyloid-depositing brain, astrocytes become hypertrophic and accumulate around senile plaques. Moreover, hippocampal astrocytes upregulate their γ-aminobutyric acid (GABA) content and enhance tonic inhibition, likely causing local circuit imbalance. It remains, however, unclear whether this effect is hippocampus specific and how it is...

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PMID: 29107186
DOI: 10.1016/j.neurobiolaging.2017.09.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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