Article
PTH 1-34 Ameliorates the Osteopenia and Delayed Healing of Stabilized Tibia Fracture in Mice with Achondroplasia Resulting from Gain-Of-Function Mutation of FGFR3.
International journal of biological sciences - 1 Jan 2017
Chen Hangang, Sun Xianding, Yin Liangjun, Chen Shuai, Zhu Ying, Huang Junlan, Jiang Wanling, Chen Bo, Zhang Ruobin, Chen Lin, Nie Mao, Xie Yangli, Deng Zhongliang
Abstract excerpt
Bone fracture healing is processed through multiple stages including the cartilaginous callus formation and its transition to bony callus. FGFR3 negatively regulates chondrogenesis and enhances osteogenesis during skeleton development. We previously found in mice carrying gain-of-function mutation of FGFR3 that FGFR3 delays the healing of un-stabilized fracture that heals mainly through endochondral ossification....
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