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Article

Hypothalamic-pituitary-adrenal axis variants and childhood trauma influence anxiety sensitivity in South African adolescents.

Metabolic brain disease - 1 Apr 2018

Womersley Jacqueline S, Martin Lindi I, van der Merwe Lize, Seedat Soraya, Hemmings Sian M J

Abstract excerpt

Anxiety sensitivity (AS) is characterised by the fear of anxiety-related symptoms and is a risk factor for the development of anxiety-related disorders. We examined whether genetic variation in three stress response genes, CRHR1, NR3C1, and FKBP5, interact with childhood trauma (CT) to predict AS in South African adolescents. Xhosa (n = 634) and Coloured (n = 317) students completed self-report measures of AS and...

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Source

Identifiers

PMID: 29101603
DOI: 10.1007/s11011-017-0138-6

Genes

FKBP5
CRHR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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