Article
Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increases energy expenditure without affecting cardiac hypertrophy.
Clinical science (London, England : 1979) - 15 Dec 2017
Diniz Gabriela Placoná, Huang Zhan-Peng, Liu Jianming, Chen Jinghai, Ding Jian, Fonseca Renata Inzinna, Barreto-Chaves Maria Luiza, Donato Jose, Hu Xiaoyun, Wang Da-Zhi
Abstract excerpt
Obesity is associated with development of diverse diseases, including cardiovascular diseases and dyslipidemia. MiRNA-22 (miR-22) is a critical regulator of cardiac function and targets genes involved in metabolic processes. Previously, we generated miR-22 null mice and we showed that loss of miR-22 blunted cardiac hypertrophy induced by mechanohormornal stress. In the present study, we examined the role of...
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