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Article

Association of mannose-binding lectin gene heterogeneity with severity of lung disease and survival in cystic fibrosis.

The Journal of clinical investigation - 1 Aug 1999

Garred P, Pressler T, Madsen H O, Frederiksen B, Svejgaard A, Høiby N, Schwartz M, Koch C

Abstract excerpt

Mannose-binding lectin (MBL) is a key factor in innate immunity, and lung infections are the leading cause of morbidity and mortality in cystic fibrosis (CF). Accordingly, we investigated whether MBL variant alleles, which are associated with recurrent infections, might be risk factors for CF patients. In 149 CF patients, different MBL genotypes were compared with respect to lung function, microbiology, and...

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Identifiers

PMID: 10449435
DOI: 10.1172/JCI6861
PMCID: PMC408526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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