Article
Mannose-binding lectin gene polymorphism predicts hospital admissions for COPD infections.
Genes and immunity - 1 Jun 2003
Yang I A, Seeney S L, Wolter J M, Anders E M, McCormack J G, Tunnicliffe A M, Rabnott G C, Shaw J G, Dent A G, Kim S T, Zimmerman P V, Fong K M
Abstract excerpt
Infection frequently causes exacerbations of chronic obstructive pulmonary disease (COPD). Mannose-binding lectin (MBL) is a pattern-recognition receptor that assists in clearing microorganisms. Polymorphisms in the MBL2 gene reduce serum MBL levels and are associated with risk of infection. We studied whether the MBL2 codon 54 B allele affected serum MBL levels, admissions for infective exacerbation in COPD and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.