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Article

Causes of blood methylomic variation for middle-aged women measured by the HumanMethylation450 array.

Epigenetics - 1 Jan 2017

Li Shuai, Wong Ee Ming, Nguyen Tuong L, Joo Ji-Hoon Eric, Stone Jennifer, Dite Gillian S, Giles Graham G, Saffery Richard, Southey Melissa C, Hopper John L

Abstract excerpt

To address the limitations in current classic twin/family research on the genetic and/or environmental causes of human methylomic variation, we measured blood DNA methylation for 479 women (mean age 56 years) including 66 monozygotic (MZ), 66 dizygotic (DZ) twin pairs and 215 sisters of twins, and 11 random technical duplicates using the HumanMethylation450 array. For each methylation site, we estimated the...

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Identifiers

PMID: 29099274
DOI: 10.1080/15592294.2017.1384891
PMCID: PMC5788416

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