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Article

The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study.

PLoS medicine - 1 Mar 2021

Perry Benjamin I, Burgess Stephen, Jones Hannah J, Zammit Stan, Upthegrove Rachel, Mason Amy M, Day Felix R, Langenberg Claudia, Wareham Nicholas J, Jones Peter B, Khandaker Golam M

Abstract excerpt

BACKGROUND: Insulin resistance predisposes to cardiometabolic disorders, which are commonly comorbid with schizophrenia and are key contributors to the significant excess mortality in schizophrenia. Mechanisms for the comorbidity remain unclear, but observational studies have implicated inflammation in both schizophrenia and cardiometabolic disorders separately. We aimed to examine whether there is genetic...

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Identifiers

PMID: 33711016
DOI: 10.1371/journal.pmed.1003455
PMCID: PMC7954314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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