Article
The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study.
PLoS medicine - 1 Mar 2021
Perry Benjamin I, Burgess Stephen, Jones Hannah J, Zammit Stan, Upthegrove Rachel, Mason Amy M, Day Felix R, Langenberg Claudia, Wareham Nicholas J, Jones Peter B, Khandaker Golam M
Abstract excerpt
BACKGROUND: Insulin resistance predisposes to cardiometabolic disorders, which are commonly comorbid with schizophrenia and are key contributors to the significant excess mortality in schizophrenia. Mechanisms for the comorbidity remain unclear, but observational studies have implicated inflammation in both schizophrenia and cardiometabolic disorders separately. We aimed to examine whether there is genetic...
Topics
- Adult
- Aged
- Aged, 80 and over
- Cardiometabolic Risk Factors
- Europe
- Genome-Wide Association Study
- Humans
- Inflammation
- Insulin Resistance
- Mendelian Randomization Analysis