Article
Regulation of glutamate metabolism and insulin secretion by glutamate dehydrogenase in hypoglycemic children.
The American journal of clinical nutrition - 1 Sept 2009
Stanley Charles A
Abstract excerpt
In addition to its extracellular roles as a neurotransmitter/sensory molecule, glutamate serves important intracellular signaling functions via its metabolism through glutamate dehydrogenase (GDH). GDH is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate in a limited number of tissues in humans, including the liver, the kidney, the brain, and the pancreatic...
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