Glutamate dehydrogenase hyperinsulinism: mechanisms, diagnosis, and treatment.

Abstract excerpt

Congenital hyperinsulinism (CHI) is a genetically heterogeneous disease, in which intractable, persistent hypoglycemia is induced by excessive insulin secretion and increased serum insulin concentration. To date,15 genes have been found to be associated with the pathogenesis of CHI. Glutamate dehydrogenase hyperinsulinism (GDH-HI) is the second most common type of CHI and is caused by mutations in the glutamate...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Child
• Share to Congenital Hyperinsulinism
• Share to Glutamate Dehydrogenase