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Characterization of genome-wide TFCP2 targets in hepatocellular carcinoma: implication of targets FN1 and TJP1 in metastasis

21 Jan 2015

Abstract excerpt

BACKGROUND: Transcription factor CP2 (TFCP2) is overexpressed in hepatocellular carcinoma(HCC) and correlated with the progression of the disease. Here we report the use of an integrated systems biology approach to identify genome-wide scale map of TFCP2 targets as well as the molecular function and pathways regulated by TFCP2 in HCC. METHODS: We combined Chromatin immunoprecipitation (ChIP) on chip along with...

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PMID: 25609232
DOI: 10.1186/s13046-015-0121-1

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